Anterior Interosseous Nerve | AIN

Anatomy

  • Motor branch of the median nerve arising about 5 cm distal to the elbow joint
  • Runs on the interosseous membrane between FPL and FDP
  • Ends in pronator quadratus and sends sensory fibres to the wrist joint
  • No cutaneous supply

Motor Supply

  • Flexor pollicis longus
  • FDP to the index and middle fingers
  • Pronator quadratus

Clinical Features

  • Unable to make an OK sign because thumb IP and index DIP flexion are lost
  • Pinch becomes pulp to pulp with straight joints
  • No sensory loss
  • The nerve most often injured in extension type supracondylar humerus fractures with posterolateral displacement
  • Other causes are forearm fractures, fibrous bands, an accessory head of FPL (Gantzer muscle) and neuralgic amyotrophy
  • Test pronator quadratus with resisted pronation in full elbow flexion

Investigations

  • EMG to confirm the lesion and exclude a partial median nerve injury
  • MRI if neuritis or a mass is suspected

Differential Diagnosis

Management

  • Most fracture related and neuritic palsies recover, so observe for 3 to 6 months
  • Exploration when there is no recovery
  • Tendon transfers for permanent loss, such as brachioradialis to FPL and side to side FDP tenodesis

Structures at Risk

  • Anterior approach to the proximal radius
  • Reduction and pinning of supracondylar humerus fractures

Reviewed by Professor Phong Tran, Head of Orthopaedic Surgery, Western Health. Last updated 10 October 2026.