TKR – Complications

Infection

  • Rate
    • 2% (Mayo clinic)
    • higher than in hips because of watershed nature of the vascular supply and lack of covering muscle.
    • risk factors
      • components with more constraint, particularly hinged prostheses
      • horizontal laminar flow theatres.
      • prolonged wound drainage.
        • In 17-50% of patients who go on to have an infection there is prolonged wound drainage.
        • RA, diabetes, psoriasis, obesity, open skin lesions on the leg, a previous knee operation and a history of previous infection.
    • Not a risk factor
      • no different with the use of cement.
  • Organism
    • The predominant organisms are S. aureus 50-65% and S.epidermidis 25-30%.
  • Management of UTI
    • should see urologist. 
    • If there is a structural reason for the UTI it should be corrected
    • if there isn’t then life long suppressive antibiotic therapy is necessary and the patient should be told there is an increased risk of infection.

Diagnosis of infection

  • Painful, warm, stiff, swollen and tender joint.
  • Differential diagnosis includes RSD, arthrofibrosis and HO.
  • Keystone of diagnosis is aspiration.

Management of infection

  • Need to make a decision about the overall goals of treatment
    • eradication vs suppression
  • Suppression
    • This doesn’t eliminate infection
    • Used in patients in whom operative intervention is too dangerous or is declined. 
    • Success rate is around 20%.
  • Debridement
    • Open debridement can be used in patients with an acute infection and well fixed prostheses. 
    • The success rate is around 30%
    • the best chance of success is when debridement occurs soon after the onset of infection and is caused by a low virulence organism such as S.epidermidis.
  • Two Stage arthrodesis
    • A staged arthrodesis with use of an intramedullary nail is associated with a 90% success rate.
    • External fixateurs have a 65% success rate.
  • Reimplantation
    • usually a two stage procedure
      • A single stage procedure is not as successful as in the hip, with a success rate of around 50-60%.
    • There are several conditions necessary for staged treatment of infection:
      • Adequate skin and soft tissue
      • Adequate bone stock
      • Intact extensor mechanism if contemplating reimplantation
      • Competent immune system
      • Need several antibiotic options to prevent the development of resistance.
    • Technique
      • debridement of all cement and the prosthesis, lavage, antibiotic spacer, parenteral IVABs, then 6 weeks off antibiotics with normal ESR/CRP and negative aspirate prior to reimplantation. 
      • A patellectomy and posterior cruciate substituting prosthesis are sometimes useful to help in skin closure in this setting. 
      • Antibiotic cement is routinely used in this setting.
    • Reported success rate is up to 97%.
  • Resection arthroplasty
    • this is an option in older patients with rheumatoid arthritis and limited functional demands. 
    • makes sitting easier but is often unstable and painful. 
    • Usual ROM is around 40 degrees.
  • Amputation
    • indicated for life threatening sepsis or local infection combined with massive bone loss. 
    • In one series of infected TKRs amputation was necessary in 6%. 
    • Patients treated with an AKA have only around a 25% chance of remaining ambulant.

Thromboembolic disease

  • The rate of DVT without prophylaxis is around 70-80%, higher than in THR, but the risk of symptomatic PE is lower than in THR.
  • Use of epidural anaesthesia decreases this risk. 
  • No conclusive proof about increased rate with tourniquet use.

Wound problems

  • blood supply
    • to the anterior skin is completely random and arises from the peripatellar anastomotic arterial ring. 
    • The branches lie in the dermis superior to the subcutaneous fascia. 
    • Any elevation of skin flaps must be deep to the subcutaneous fascia.
  • Lateral release
    • There is a higher rate of wound complications with a lateral release because this reduces oxygen tension to the lateral skin. 
    • If a lateral release is performed one should attempt to preserve the superior lateral geniculate artery, which is found at the musculotendinous junction of the vastus lateralis.
  • Risk factors
    1. obesity,
    2. rheumatoid arthritis,
    3. malnutrition,
    4. nicotine abuse,
    5. diabetes
    6. chemotherapy
  • CPM
    • in excess of 40 degrees in the first three days decreases oxygen tension in the flaps and may have a higher rate of wound breakdown.
  • Continuous wound drainage
    • without obvious infection
      • is treated with immobilization and dressings. 
    • If drainage persists for more than 5 days an open debridement should be performed.
  • Superficial soft tissue necrosis
    • should be managed with debridement and skin grafting.
  • Full thickness skin loss
    • medial head of gastrocnemius myocutaneous flap. 
    • The medial head is preferred because it is longer and doesn’t have to traverse the fibula so there is more effective length.

Neurovascular complications

Peroneal nerve palsy

  • Rate
    • 0.58% of all knees
  • Risk factors
    • valgus deformity (3%) and flexion contracture. 
    • epidural anaesthesia
      • Epidural anaesthesia is probably not wise in a patient with a valgus knee and or laminectomy.
    • previous laminectomy. 
  • Not Risk factors
    • Peroneal nerve palsy is not related to
      • age,
      • gender,
      • type of arthritis
      • duration of tourniquet use.
  • Treatment
    • Initial
      • As soon as the problem is diagnosed the dressing should be released and the knee flexed 20 degrees, the hip extended, and external rotation of the leg prevented with a soft pillow under the hip. 
      • The area around the head of the fibula should be observed for an expanding haematoma.
    • Operative
      • Operative intervention should be considered at 3 months if there is no improvement. 
        • 97% improvement rate after neurolysis, with 2/3 of patients making a full recovery. 
        • Only 1/3 of patients made a recovery without a neurolysis. 
        • pre-neurolysis severity did not correlate with the results of neurolysis.
      • There has been no benefit demonstrated in exploring and prophylactically releasing the nerve in high risk knees.
  • Prognosis
    • Complete recovery post palsy is rare.

Arterial injury

  • Rate of arterial damage is around 0.1%
  • Prevention
    • If the pulses are impalpable the procedure should be done without a tourniquet to decrease the risk of thrombosis and plaque fracture in atherosclerotic arteries.
  • Treatment
    • If there is any suspicion of a vascular injury the tournique should be released prior to the insertion of components. 
    • urgent on table angiogram
    • vascular consultation
  • Prognosis
    • up to 25% lead to amputation.

Extensor mechanism problems

  • Rate
    • Problems with the extensor mechanism are responsible for up to 50% of revisions.
  • Malpositioning of the components is often the cause of this:
    1. Internal rotation of the femoral component
    2. Medial shift of the femoral component
    3. Internal rotation of the tibial component
    4. Medial shift of tibial component
    5. Lateral placement of the patella button – the button should be placed on the medial border of the patella.
  • Patella
    • Assessment of maltracking
      • patella maltracking can only be assessed after the tourniquet is deflated to free up the quadriceps.
    • Patella Resection
      • Patellar resection that leaves less than 15mm of bone substantially increases anterior patellar strain.  When the patella is cut only a minimum of bone should be removed from the lateral facet, to create symmetry in the patella with decreased rates of maltracking.  Cutting equal amounts of bone from the medial and lateral facets will actually create an asymmetrical patella.
    • A large central cement plug increases strain compared with peripheral, smaller holes.
    • Loosening of a cemented patellar component occurs in 2%.  Higher rates are found in noncemented components.
    • Metal backed patellae have had a high failure rate.

Patella Fractures

  • Risk factors for patellar failure include:
    1. excessive body weight,
    2. increased postoperative knee flexion (>115 degrees),
    3. male gender
    4. increased activity.

Patellar clunk syndrome

  • This is due to the development of a fibrous nodule at the posterior aspect of the quadriceps tendon and proximal pole of the patella.
  • Treatment is open or arthroscopic debridement of the nodule.

Tendon rupture

  • This has a 1% incidence and is treated by an augmented repair e.g. with semitendinosis.

Stiffness

  • Range of motion usually increases steadily over the first three months and then to a lesser extent over the next nine months.
  • CPM hasn’t been shown to decrease hospital stay or increase ROM.
  • Diagnosis
    • Physical examination to rule out infection
    • XR to rule out overstuffing or patellar maltracking.
    • Bone scan if stiffness develops more than a year postoperatively.
    • Joint aspiration
  • Treatment
    • Physiotherapy
      • should be continued if getting response. 
      • If there is a plateau or no response by three months, and infection has been excluded, then an MUA can be performed.
    • MUA can be performed at several months post surgery and the results retained to some extent
      • Complications of MUA
        • Supracondylar fracture
        • Patellar tendon avulsion
        • Myositis ossificans
        • Wound breakdown
    • Operative
      • If MUA is ineffective an arthroscopic debridement can be done but the results are unpredictable, and poor in the setting of arthrofibrosis.
      • The next step is revision with a PCL substituting prosthesis and increased flexion gaps while all adhesions are removed.

Supracondylar femoral fracture

  • Rate: 1%.
  • Risk factors
    • Increased in patients with osteoporosis e.g. secondary to RA or chronic steroid use.
  • Notching
    • Contribution of notching is controversial with some finding an increased rate of supracondylar fracture and others no difference, but it should be avoided, particularly in osteoporotic bone. 
    • If a notch is discovered intraoperatively should consider use of a stemmed prosthesis.
  • In open treatment, one should have long stemmed revision components as well as an IMN in case the implant is unstable. 
    • IM nailing is simpler, biomechanically more sound and less prone to failure than blade plates. 
    • he results are much better with intramedullary nailing.