• G + cocci in clusters
  
• S aureus
  
• S epidermidis

Exotoxins

• proteolytic
• haemolytic
• pyogenic
• enterotoxin

• Flucloxacillin
• (Vancomycin)

• G + cocci in chains
  
• Beta-haemolytic
• Group A
  • S pyogenes
    
• Group B
  • S agalactinae
    
• Group G
  • S faecalis
    
  • Enterococcus
    
• Non beta-haemolytic
  
• S pneumoniae
  
• S viridans

Exotoxins

• haemolysins
• hyaluronidase,
• streptokinase

• Penicillin

• Heterogenous group
  
  • E coli
    
  • Klebsiella Proteus
    
  • Enterobacter
    
  • Serratia
    
  • Shigella
    
  • Vibrio cholera

Endotoxin

• fever
• hypotension
• inflammation

Exotoxin

• diarrhoea

Various sensitivities

• Gentamicin
  • covers most
• (3rd generation cephalosporin)

G – bacillus
H influenzae

• Augmentin
• (Cefotaxime)

Group A strep (S pyogenes)
Other aerobes/ anaerobes common

• Debride
• Empiric triple AB

G + bacillus Prevent by TT/ TIG
Clostridium tetani (tetanospasmin, tetanolysin)

• Debride
• Penicillin

• AFB
• Mycobacterium leprae
  
  

• Sulphones + Rifampicin
• Prednisone for acute neuro loss
• Treatment Charcot joints